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Summary of the Day

Pulseless Vtach Rx

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Question of the Day

A 63-year-old man with normal renal function has a thoracic epidural catheter placed for postoperative analgesia following thoracotomy for left lower lobectomy. His epidural catheter is removed on postoperative day 3. Which of the following is the EARLIEST time after removal of the epidural catheter that fondaparinux can be restarted?

Question of the Day
A 63-year-old man with normal renal function has a thoracic epidural catheter placed for postoperative analgesia following thoracotomy for left lower lobectomy. His epidural catheter is removed on postoperative day 3. Which of the following is the EARLIEST time after removal of the epidural catheter that fondaparinux can be restarted?
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Correct Anwser

Explanation

Fondaparinux (Arixtra©) is an antithrombotic medication that inhibits Factor Xa. The plasma half-life is 1721 hours and it is normally administered by subcutaneous injection for the prevention of venous thromboembolism. There are concerns about the use of neuraxial anesthesia for patients receiving fondaparinux. Clinical studies have demonstrated safety for patients receiving prophylactic dosing of fondaparinux with removing epidural catheters 36 hours after the last dose of fondaparinux and delaying repeat dosing of this drug until more than 6 hours after catheter removal.

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