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Succinycholine: lower esophageal sphincter pressure

Classic teaching espouses that fasciculations in the abdominal wall muscles cause a transient increase in gastric pressure, which is offset by a concurrent increase in SCh-induced LES tone.More recent animal studies have suggested that the changes in both intragastric and LES pressure are trivialand not statistically significant ramide in premedication for or induction of anaesthesia to eliminate the depressant effect of atropine on the LOS pressure appears to be indicated.”


  1. G Smith, R Dalling, T I Williams Gastro-oesophageal pressure gradient changes produced by induction of anaesthesia and suxamethonium. Br J Anaesth: 1978, 50(11);1137-43 Link
  2. S Laitinen, R E Mokka, J V Valanne, T K Larmi Anaesthesia induction and lower oesophageal sphincter pressure. Acta Anaesthesiol Scand: 1978, 22(1);16-20 Link
  3. W P Cook, R R Schultetus Lower esophageal sphincter integrity is maintained during succinylcholine-induced fasciculations in dogs with “full” stomachs. Anesth. Analg.: 1990, 70(4);420-3 Link