Inhalational anesthetics (halogenated anesthetics and nitrous oxide) decrease the amplitudes and increase the latency of SSEPs in a dose-dependent manner. (1)
Midazolam has little effect below 150mcg/kg.
Propofol has minimal effects between 120-200mcg/kg/min
Ketamine and Etomidate are acceptable as well.(2)
Opioids have minimal effects on SSEPs or MEPs.
At higher doses: (3)
- Etomidate increasesboth amplitude and latency.
- Thiopental decreasesamplitude and increases
- Midazolam hasno effect on amplitude but increases
Dexmedetomidine has minimal effects on SSEP monitoring. (4)
Other References
- Recommendations of the International Society of Intraoperative Neurophysiology for intraoperative somatosensory evoked potentials. Link
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