Minute ventilation is determined by tidal volume multiplied by respiratory rate. In pressure control ventilation (PCV), inspiratory pressure and inspiratory time (Ti) (or respiratory rate and I:E ratio) are set, and tidal volume and inspiratory flow will vary. Tidal volume can vary greatly based on compliance or resistance in the lungs. Ultimately this means an expected tidal volume may not be guaranteed, and thus minute ventilation can vary greatly.
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