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Metformin: Contrast dye

  • Together, can cause lactic acidosis
  • However, this rare complication occurs only if the contrast medium causes renal failure,and the patient continues to take metformin in the presence of renal failure.
  • Because metformin is excreted primarily by the kidneys, continued intake of metforminafter the onset of renal failure results in a toxic accumulation of this drug and subsequentlactic acidosis