Hypoxic pulmonary vasodilation
Last updated: 03/05/2015
For information on Hypoxic Pulmonic Vasoconstriction, see Hypoxic Pulmonary Vasoconstriction
While Hypoxic Pulmonary Vasoconstriction is a well-described phenomena, mammalian lungs may be capable of vasodilating following a hypoxemic challenge (pO2 < 25 mm Hg). It is thought that this response is mediated by adenosine. This effect is well described in sea lions, in which case it is mediated by hydrogen sulfide.
- Gottlieb JE, Peake MD, Sylvester JT. Adenosine and hypoxic pulmonary vasodilation. Am J Physiol. 1984 Oct;247(4 Pt 2):H541-7. PubMed Link
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