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Hypoxic pulmonary vasodilation

For information on Hypoxic Pulmonic Vasoconstriction, see Hypoxic Pulmonary Vasoconstriction

While Hypoxic Pulmonary Vasoconstriction is a well-described phenomena, mammalian lungs may be capable of vasodilating following a hypoxemic challenge (pO2 < 25 mm Hg). It is thought that this response is mediated by adenosine. This effect is well described in sea lions, in which case it is mediated by hydrogen sulfide.


  1. Gottlieb JE, Peake MD, Sylvester JT. Adenosine and hypoxic pulmonary vasodilation. Am J Physiol. 1984 Oct;247(4 Pt 2):H541-7. PubMed Link