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HCTZ: mechanism of action

Hydrochlorothiazide is a sulfonamide derivative. Itblocks the Na/Cl co-transporter in the early segment of the distal convoluted tubule. Thiazides INCREASE calciumlevels in the blood. Other side effects include:hypokalemia, hypochloremic metabolic alkalosis, hyperuricemia, hyperglycemia, hyponatremia.