Search on website
chevron-left-black Keywords

Eaton-Lambert: Mechanism

Rare autoimmune disorder, causes peripheral muscle weakness. Antibodies are directed against calcium channels at the neuromuscular junction. Frequently a complication of malignancy (most commonly small cell lung ca). Cancer treatment relieves symptoms. Strength increases with increased use. May have autonomic abnormalities (gastroparesis, orthostatic hypotension or urinary retention).