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Eaton-Lambert: Mechanism
Last updated: 03/06/2015
Rare autoimmune disorder, causes peripheral muscle weakness. Antibodies are directed against calcium channels at the neuromuscular junction. Frequently a complication of malignancy (most commonly small cell lung ca). Cancer treatment relieves symptoms. Strength increases with increased use. May have autonomic abnormalities (gastroparesis, orthostatic hypotension or urinary retention).
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