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Coag factors in hepatic disease

Considerations in the perioperative period:

  • FFP 10-20 ml/Kg should correct PT to near normal for 12-24h
  • Cryoprecipitate also used: higher conc of FVIII and fibrinogen
  • Platelet transfusion indicated if <60.000
  • Vitamin K 10mg SC x3d, only effective if cholestatic disease
  • RBC transfusion can precipitate encephalopathy due to nitrogen load
  • rFVII only for bleeding not responding to other measures, Relatively contraindicated in DIC