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ANP: Factors causing release

Atrial natriuretic peptide (ANP) is a peptide hormone released by cardiac myocytes in response to atrial stretching due to increased extracellular volume/volume overload. This stretch leads to the precursor ProANP being cleaved and released. The ProANP is cleaved by serine proteases to ANP and urodilatin in the kidney. ANP has vasodilatory, diuretic, and natriuretic effects resulting in secondary effects such as reduction ofextracellular fluidvolume (edema), improvedejection fraction, improved organ perfusion, decreasedblood pressure, and increased serumpotassium.


  1. Ichiki T, Burnett JC. Atrial Natriuretic Peptide - Old But New Therapeutic in Cardiovascular Diseases. Circ J. 2017;81(7):913-919. PubMed Link