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Aldosterone: Regulation

  • Released from zona glomerulosa of the adrenal glands
  • Responsible for long term control (days) of blood pressure and plasma osmolarity
    • Kidneys alter total body sodium and water balance to restore blood pressure to normal
  • Increased release
    • ACTH (anterior pituitary)
  • Sympathetic stimulation (surgery, stress) → increased ACTH secretion
  • Glucocorticoids → inhibit ACTH secretion
    • Angiotensin II (renin angiotensin aldosterone system)
    • Hyperkalemia