Pregnancy: Plasma proteins


Normal hemoglobin is 12 g/dL. Clotting factors (I, VII, VIII, IX, X, XII) are elevated, protein S (anticoagulant) is decreased, and there is acquired resistance to protein C. Pregnancy is thus a hypercoagulable state.

According to Gabbe, “There is increased nitrogen retention in pregnancy in both maternal and fetal compartments. There is an increase of approximately 0.9 kg of maternal fat-free mass by 27 weeks. There is a significant decrease in most fasting maternal amino acid concentrations in early pregnancy prior to the accretion of significant maternal or fetal tissue…there is a 15-percent increase in protein synthesis during the second trimester and a further increase in the third trimester by about 25 percent.”

Proteins in Pregnancy

  • Hemoglobin: decreases to 12 g/dL
  • Clotting Factors (I, VII, VIII, IX, X, XII): elevated
  • Anticoagulants (S): decreased (as well as acquired resistance to protein C)
  • Amino Acids: increased by the 2nd trimester


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