Ketorolac: renal function


What kind of pharmacologic agent is it? NSAID

Mechanism of action? Not completely understood, thought to work by inhibiting prostaglandins

USES: pain

Pharmacokinetics Liver metabolism Renal excretion Peak: 1 hr

Dose: Patients age 17 to 64: 20 mg PO once followed by 10 mg q4-6 hours prn not > 40 mg/day Patients age ≥ 65, renally impaired, and/or weight < 50 kg (110 lbs): 10 mg PO once followed by 10 mg q4-6 hours prn not > 40 mg/day

Side Effects of Ketorolac

  • GU/RENAL: cystitis, dysuria, hematuria, increased urinary frequency, interstitial nephritis, oliguria/polyuria, proteinuria, renal failure, urinary retention
  • GI: anorexia, dry mouth, eructation, esophagitis, excessive thirst, gastritis, glossitis, hematemesis, hepatitis, increased appetite, jaundice, melena, rectal bleeding
  • CV: congestive heart failure, palpitation, pallor, tachycardia, syncope
  • Dermatologic: alopecia, photosensitivity, urticaria
  • HEME: ecchymosis, eosinophilia, epistaxis, leukopenia, thrombocytopenia
  • Nervous System: abnormal dreams, abnormal thinking, anxiety, asthenia, confusion, depression, euphoria, extrapyramidal symptoms, hallucinations, hyperkinesis, inability to concentrate, insomnia, nervousness, paresthesia, somnolence, stupor, tremors, vertigo, malaise Reproductive, female: infertility
  • Respiratory: asthma, cough, dyspnea, pulmonary edema, rhinitis
  • Special Senses: abnormal taste, abnormal vision, blurred vision, hearing loss


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