Fenoldopam: Renal effects

Fenoldopam is a selective DA1-receptor agonist that has many of the benefits of DA but with little or no alpha or beta adrenoceptor or DA2-receptor agonist activity. Fenoldopam has been shown to exert hypotensive effects characterized by a decrease in peripheral vascular resistance, along with an increase in renal blood flow, diuresis, and natriuresis. It is indicated for patients undergoing cardiac surgery and aortic aneurysm repair, because of its antihypertensive and renal-sparing properties. It is also indicated for patients who have severe hypertension, particularly those with renal impairment.