Cytochrome 450: Ultrarapid Metabolism

Pharmacokinetics is the study of how a drug is affected by the body (i.e. Absorption, distribution, metabolism, and excretion). Differences in genetic make-up alter a patient’s ability to respond to or metabolize a drug. Cytochrome P450 enzymes’ activities are governed by genetic polymorphisms resulting in phenotypes with varying abilities to perform their metabolic roles including reduced, normal, and increased metabolic activity. [More…]