Coag factors in hepatic disease

Considerations in the perioperative period:

• FFP 10-20 ml/Kg should correct PT to near normal for 12-24h
• Cryoprecipitate also used: higher conc of FVIII and fibrinogen
• Platelet transfusion indicated if <60.000
• Vitamin K 10mg SC x3d, only effective if cholestatic disease
• RBC transfusion can precipitate encephalopathy due to nitrogen load
• rFVII only for bleeding not responding to other measures, Relatively contraindicated in DIC