The “Strong Ion Difference” (SID) is defined as the difference between the completely dissociated cations (e.g. Na+, K+, Ca2+, and Mg2+) and anions (Cl-, lactate-) in plasma. As not all strong ions can be measured, the apparent SID (SIDa) is defined as the difference between the sum of the measured strong cations and the sum of the net charge of the measured major strong anions. [More…]
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