Long QT syndrome – Medications


The QT interval is normally < 450 ms in males, < 470 ms in females.

Prolongation is associated with a risk of the arrhythmia torsades de pointea (TdP), a potentially life threatening ventricular arrhythmia, when drugs that further prolong the QT are administered. Examples of these drug classes are include:

  1. Antiarrhythmics: Amiodarone, Satalol, Quinidine, Procainamide
  2. Antibiotics: Ciprofloxacin, Levofloxacin, Moxifloxacin, Erythromycin, Ketoconazole
  3. Antidepressants: Amitriptyline, Imipramine, Desipramine, Fluoxetine, Sertaline
  4. Antipsychotics: Droperidol, Haloperidol, Thioridazine
  5. Others: Dolasetron, Zofran, Methadone, all the halogenated anesthetics


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  1. Peter Nagele, Swatilika Pal, Frank Brown, Jane Blood, J Philipp Miller, Joshua Johnston Postoperative QT interval prolongation in patients undergoing noncardiac surgery under general anesthesia. Anesthesiology: 2012, 117(2);321-8