Anemia has been observed in vivo to produce a hypercoaguable state. Platelet function, as measured by multiple electrode aggregometry and rotational thrombelastometry (TEG) has been shown to exhibit accelerated platelet aggregation when taken from increasingly anemic blood samples from 13 volunteers.
Anemia also affects the coagulation cascade. In a sample of 29 patients with chemotherapy induced anemia, decreased hemoglobin was associated with a delay in the initiation of the coagulation cascade as well as a clot that is both stronger and has superior viscoelastic properties.
More studies are necessary to elucidate the clinical impact of anemia on blood hemostasis.
- Wilfried W H Roeloffzen, Hanneke C Kluin-Nelemans, Lotte Bosman, Joost Th M de Wolf Effects of red blood cells on hemostasis. Transfusion: 2010, 50(7);1536-44 [PubMed:20158685]