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Key Points

  • Supraglottic airway devices (SADs) are placed in the superior part of the glottis and do not extend into the trachea. Compared with endotracheal tubes (ETTs), these devices are associated with fewer airway-related complications and improved postoperative recovery.1,2,8
  • SADs are recommended for rescue ventilation after failed attempts at intubation and masked ventilation.1
  • SADs are available in different generations: first-generation devices provide basic ventilation, while second- and third-generation devices incorporate features that have shown reduced aspiration risk and allow intubation through the device.1,2,3
  • SADs should be placed in the optimal anatomical position to ensure proper airway seals and allow sufficient gas exchange.3

Introduction

  • SADs are ventilation devices placed above the glottis, providing airway support without entering the trachea.1
  • The devices include a variety of single-use and reusable options used in both elective and emergency airway management.1,2,3
  • SADs have been recommended as non-invasive tools for both anticipated and unanticipated difficult airway management, including use as primary devices and as rescue options when face mask ventilation or tracheal intubation fails.1,2,3
  • SADs are a key component of modern airway management. The development of these devices began in the early 1980s with the laryngeal mask airway created by Dr. Archie Brain.2
  • These devices have undergone rapid development and have been widely adopted in the clinical setting.2
  • Compared to ETTs, SADs have several advantages, including easier insertion and reduced need for neuromuscular blocking agents.2
  • SADs have been shown to eliminate the need for translaryngeal placement, thereby reducing associated cardiovascular responses and contact with the vocal cords.2

Classification of Supraglottic Airways and Their Features

Table 1. An overview of the classification of SADs, example devices, key features and functions, and important considerations of each generation.1,2,4-10

  • First-generation SADs are characterized by a simple breathing tube that is equipped with a mask or an opening positioned at the laryngeal inlet.1,2
  • Relative to first-generation SADs, second-generation SADs have an overall reduced airway morbidity. A lower incidence of sore throat, dysphagia, and hoarseness is also observed.2,5-7
  • Improved hemodynamic stability and higher oropharyngeal leak pressures have been reported with second-generation SADs, along with shorter recovery periods and reduced overall hospital stay.2,5,7
  • Third-generation SADs are characterized by self-pressurizing and dynamic sealing properties, which allow for an improved ease of intubation through the device and greater stability under varying airway pressures.2,4

Table 2. An overview of the commonly used devices and their features.1-3,7

Figure 1. A list of examples of (A) first-generation supraglottic airway devices, (B) second-generation supraglottic airway devices with separate ventilation and gastric channels, and (C) third-generation supraglottic airway devices. Source: Van Zundert A AJ, et al. Supraglottic airway devices: Present state and outlook for 2050. Anesth Analg. 2024; 138(2), 337–349.4

  • Important features to consider include the integrity of the esophageal seal, the angle of curvature in devices with rigid shafts, the presence of a gastric channel, and the thickness and shape of the cuff.3
    • A secure esophageal seal and cuff is considered essential for minimizing aspiration risk and enabling ventilation with higher peak airway pressures.3
    • The angle of curvature is evaluated because it influences the ease of insertion. Inappropriate curvature may be associated with mechanical injury and compromise of the protective barrier.3
    • The inclusion of a gastric channel is recognized as a means of reducing the likelihood of regurgitation.3
  • The material used for SAD construction (silicone, polyvinyl chloride, or elastomere) and the presence of an integrated bite block should also be noted.3
    • A reduced risk of airway compromise has been demonstrated when an integrated bite block is incorporated, as it protects against device occlusion or rupture if the patient bites down.1
  • The 2nd- and 3rd-generation SAD designs have incorporated channels to direct gastric contents away from the airway and integrated cuff pressure measurement.6,7

Indications

Airway Rescue

  • SADs are employed in “cannot intubate, cannot oxygenate” situations.1-3
  • SADs have been shown to prevent the need for emergency surgical airway and are recommended by multiple difficult airway guidelines.3
  • Complex cases have utilized second-generation SADs which include obese patients, laparoscopic surgery, and obstetric patients.1,3,5-7
    • SADs have demonstrated similar efficacy to ETTs with fewer postoperative complications during laparoscopic surgery.3,6,7
    • Access for endotracheal Intubation:
      • Some SADs are specifically designed to facilitate ETT intubation. Examples include: i-gel®, LMA® Fastrach™, air-Q®, and Ambu AuraGain™.2,3,5,6
      • These devices allow visualized intubation using fiberoptic bronchoscopy.6
      • Blind intubation can also be accomplished in select devices.2

Primary Airway Management

  • SADs can be used for primary airway management, which include ambulatory anesthesia and short-duration procedures with spontaneous ventilation.3
    • Compared with ETTs, SADs have a lower incidence of postoperative cough, hoarseness, and nausea when used as primary airway management.8
  • Emergency and pre-hospital airway management:
    • SADs are used in out-of-hospital airway management, particularly by paramedics with limited experience in endotracheal intubation.3
    • As supported by international resuscitation guidelines, SADs have been used during cardiac arrest resuscitation.2

Special Considerations

Obesity/Obstructive Airway Disease

  • Device failure due to inadequate ventilation is more likely in obese patients with obstructive airways disease.1-3

Patients with a High Risk of Aspiration and Regurgitation

  • Obstructive sleep apnea, gastroesophageal reflux, nausea/vomiting, and obesity should be considered.1,3

Pediatric Anesthesia

  • The use of SADs has reduced the incidence of perioperative respiratory adverse events in infants compared to ETTs.3
  • SADs can be used for neonatal resuscitation as an alternative to mask ventilation or ETT in term or near-term infants.2,3

Use During Extubation

  • SADs have facilitated controlled extubation by minimizing hemodynamic stimulation and coughing and have allowed post-extubation airway assessment with flexible bronchoscopy.1,2,4,7

Use During Percutaneous Dilatational Tracheostomy (PDT)

  • SADs may be used during PDT as an alternative to ETT for ventilation in ICU patients.3

Perioperative Use

  • Although caution is required, SADs may be used in Trendelenburg, Lithotomy, prone positioning, and rescue ventilation after accidental prone extubation.3

Technique

Standard Technique of SAD Insertion

  • First, the appropriate device size should be selected.4,10
  • The posterior surface should then be lubricated, and the patient’s head should be positioned in the sniffing position.4,10
  • The mouth should be opened, and the device should be advanced along the hard palate until resistance is encountered.4,10
  • The cuff should then be inflated, and correct placement of the device should be confirmed.4,10

Optimal Airway Seal

  • Two seals should be produced to ensure a functional fit: one for the gastrointestinal tract and one for the respiratory tract, which seals the glottic entrance.4
  • The esophageal seal serves as a functional barrier that prevents contamination of the airway by secretions, blood, or pus, while also reducing gastric inflation and the risk of aspiration.4
  • The epiglottis should be rested outside of the airway device, and the ideal intracuff pressure should range between 40–60 cm H2O.4
    • An optimal seal should produce a normal capnogram, adequate air entry, and excellent gas exchange. This is indicated by an Oropharyngeal Leak Pressure greater than 25 cm H2O, and peripheral oxygen saturation (SpO2) levels greater than 95%.4

Optimal Anatomical Position

  • A properly positioned SAD should have its tip resting against the upper esophageal sphincter, with the cuff filling the hypopharynx and sitting behind the cricoid cartilage.4
  • The device’s opening should directly oppose the glottis, while the cuff’s sides rest in the pyriform fossae.4
  • The epiglottis should be located externally to the device and aligned with the proximal portion of the mask.4
  • When correctly placed, the SAD forms two effective seals for both the respiratory and digestive tracts.4

Figure 2. Examples of correctly positioned SADs and anatomically malpositioned devices inserted blindly with potentially functional substandard outcomes. ETT indicates endotracheal tube; PVC, polyvinyl chloride; SAD, supraglottic airway device; VLMA, video laryngeal mask airway. Source: Van Zundert A AJ, et al. Supraglottic airway devices: Present state and outlook for 2050. Anesth Analg. 2024; 138(2), 337–349.4

Complications

Trauma and Local Injury

  • Complications related to SAD placement are more likely to be encountered in patients with traumatic airway injuries.1
  • Complications include worsening of airway trauma, inadequate oxygenation, and nerve injury.1,9

Device-Related Problems

  • Some classifications of SADs are not given protection against aspiration as a cuffed endotracheal tube.7
  • Mispositioning of the device has resulted in clinical malfunction and interference with gas exchange, loss-of-airway, and gastric inflation.4
  • If a difficult intubation is expected, SADs should be used cautiously.
    • Poor outcomes can occur when an SAD is used to avoid an anticipated difficult airway without a proper backup plan.4

Airway and Ventilation Issues

  • Situations with expected difficulty inserting or ventilating with an SAD has suggested a reduced efficacy of the device.3
    • Examples include reduced mouth opening, fixation of the cervical spine or the use of manual in-line stabilization, abnormal or absent dentition, airway pathology or edema at the glottic, supraglottic, or subglottic levels, elevated intra-abdominal pressure, and restricted airway access due to surgical positioning.3
  • When patients are placed in lithotomy, Trendelenburg positions, there may be elevated intraabdominal pressure leading to ventilation issues, as well as increased aspiration risk.3
  • When patients are in the prone position, there will be restricted airway access.3

Cardiopulmonary Effects

  • SADs can be less suitable due to inadequate anesthetic depth or inexperienced operators which can lead to increased risk of laryngospasm, loss of airway, or improper placement.3
  • Elevated airway pressures such as poor lung compliance and pneumoperitoneum can exceed the seal capability of some SADs, resulting in an increased leak or aspiration risk.3,4

References

  1. Ramachandran SK, Kumar AM. Supraglottic airway devices. Respiratory Care. 2014; 59(6), 920–932. PubMed
  2. Zhang K, Zhou M, Zou Z, et al. Supraglottic airway devices: a powerful strategy in airway management. Am J Cancer Res. 2024; 14(1), 16–32. PubMed
  3. Gordon J, Cooper, RM, Parotto M. Supraglottic airway devices: indications, contraindications and management. Minerva anestesiol. 2018; 84(3), 389–97. PubMed
  4. Van Zundert A AJ, Gatt SP, Van Zundert TCRV, et al. Supraglottic airway devices: Present state and outlook for 2050. Anesth Analg. 2024; 138(2), 337–49. PubMed
  5. Zhang J, Drakeford PA, Ng V, et al. Ventilatory performance of AMBU® AuraGainTM and LMA® SupremeTM in laparoscopic surgery: A randomised controlled trial. Anaesth Intensive Care. 2021;49(5):395-403. PubMed
  6. Shin HW, Yoo HN, Bae GE, et al. Comparison of oropharyngeal leak pressure and clinical performance of LMA ProSealTM and i-gel® in adults: Meta-analysis and systematic review. J Int Med Res 2016; 44(3):405-18. PubMed
  7. Sharma B, Sahai C, Sood J. Extraglottic airway devices: technology update. Medical devices (Auckl). 2017;10:189–205. PubMed
  8. De Carvalho CC, Kapsokalyva I, El-Boghdadly K. Second-generation supraglottic airway devices versus endotracheal intubation in adults undergoing abdominopelvic surgery: A systematic review and meta-analysis. Anesthesia & Analgesia. 2025; 140(2). PubMed
  9. Jain U, McCunn M, Smith, CE, Pittet JF. Management of the traumatized airway. Anesthesiology. 2016;124(1), 199–206. PubMed
  10. Lyng JW, Baldino KT, Braude D, et al. Prehospital Supraglottic Airways: An NAEMSP Position Statement and Resource Document. Prehospital emergency care, 2022; 26(sup1), 32–41. PubMed