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NMJ AChR upregulation causes

According to Miller, “In conditions associated with insulin resistance, there seems to be a proliferation of AChRs beyond the junctional area… the extrajunctional immature receptors can reappear soon after upper and lower motor denervation and in certain pathologic states (e.g., burns, immobilization, chronic muscle relaxant therapy, loss of electrical activity).”

Upregulation of Extrajunctional AChR (see Miller Chapter 14)

  • Insulin resistance
  • Burns
  • Immobilization
  • Chronic muscle relaxants
  • Loss of electrical activity