Factors causing prolonged neuromuscular blockade

Drugs

1. Antibiotics

• Aminoglycosides: Gentamicin & Tobramycin
• Tetracyclines
• Polymixins
• The following antibiotics do not prolong neuromuscular blockade: Erythromycin, penicillin, and cephalosporins.

2. Anticholinesterases 3. Calcium Channel Blockers 4. Local Anesthetics 5. Volatile Anesthetics

Abnormal Physiologic States

1. Hepatic Dysfunction
2. Hypothermia
3. Acidosis or Alkalosis

Electrolyte Abnormalities

1. Hypernatremia
2. Hypocalcemia
3. Hypokalemia
4. Lithium

User: Bassam Kadry, 19:19, 11 July 2009 (UTC)