- Nonbarbiturate hypnotic, no analgesic activity, used for induction & sup of anesthesia.
- Decreases cerebral metabolism, cerebral blood flow, and intracranial pressure. (superior to propofol in maintaining cerebral perfusion pressure)
- Effects on EEG: initial increase α amplitude followed by progressive decrease in activity
- Periods of burst suppression occur at higher doses. Use with caution in patients with focal epilepsy
- A single induction dose may inhibit 11β-hydroxylase ⇒Adrenocortical suppression
- May last 4-8 hours.
- Pharmacology
- Induction dose: 0.1-0.4 mg/kg Onset 30-60 seconds DOA 3-10 minutes
- A/e: thrombophlebitis, laryngospasm, hiccups, myoclonus, nausea/vomiting
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