(ADAPTED FROM THE ABA CCM CONTENT OUTLINE)
1. Central Nervous System
a. Altered mental status
i. Coma 
ii. Delirium
iii. Hallucinations/Agitation
iv. Other (e.g., hypoxic/metabolic encephalopathy)
b. Brain Death
c. Degenerative Disease of the Brain
d. Head Injury, Closed or Open 
e. Infectious
i. Abscess
ii. Encephalitis
iii. Meningitis/Ventriculitis
f. Neuromuscular Disorders
i. Critical Illness Polyneuropathy
ii. Demyelinating/Guillain-Barré Syndrome
iii. Myasthenia Gravis
iv. Myopathy
g. Seizures and Status Epilepticus
h. Spinal Cord Injury
i. Stroke
1. Embolic/Thrombotic
2. Hemorrhagic (Subarachnoid, Subdural, Epidural)
3. Ischemic
j. Subarachnoid, Subdural, Epidural Hematoma
k. Vascular Malformations (e.g., Aneurysms, AVMS)
l. Pituitary Disorders (e.g., Acromegaly, Sheehan’s Syndrome)
2. Cardiovascular
a. Cardiac Transplantation, Rejection, Complications
b. Congenital Heart Disease in Adults
c. Coronary Artery Disease, Myocardial Ischemia/Infarction
d. Hypertension
1. Pulmonary Hypertension
2. Systemic Hypertension
e. Infectious
1. Endocarditis
2. Myocarditis
3. Pericarditis
f. Myocardial Function/Dysfunction
1. Left Ventricular
2. Right Ventricular
g. Peripheral Vascular Disease
1. Aneurysms, Thoracic, Abdominal
2. Dissections
h. Rhythm Disturbances
1. Atrial Flutter/Fibrillation
2. Heart Block, Asystole, Pulseless Electrical Activity, Supraventricular Tachycardia, Ventricular Tachycardia/Fibrillation
i. Shock States 
1. Cardiogenic
2. Distributive (Sepsis, Neurogenic, Anaphylactoid)
3. Hypovolemic (e.g., Hemorrhagic Shock)
4. Obstructive (e.g., Pulmonary Embolism)
j. Structural 
1. Cardiac Contusion
2. Stress-Induced Cardiomyopathy (Takosubo Syndrome)
3. Acquired ASD, VSD
4. Cardiomyopathy
5. Noninfectious Myocarditis
6. Pericardial
7. Valvular
l. Circulatory Support Systems
1. ECMO
2. Pacemakers/Defibrillators
3. Left or Right Ventricular Assist Device
4. Intraaortic Balloon Pump
3. Pulmonary
a. Airway Diseases
1. Obstructive
2. Reactive
3. Restrictive
b. Airway Disruption (e.g., Pneumothorax)
c. Aspiration
d. Chest Trauma (e.g., Pulmonary Contusion, Flail Chest)
e. Embolic Disorders (Air, Fat, Thromboembolic)
f. Infection
1. Empyema/Abscess
2. Mediastinitis
3. Pneumonia
i. Community-Acquired
ii. Health Care/Ventilator Associated
4. Tracheobronchitis
g. Lung Transplantation, Rejection, Complications
h. Pleural Effusion
i. Respiratory Failure
1. ARDS
2. TRALI
j. Volutrauma/Barotrauma
k.Ventilatory Support
1. Invasive Ventilation Modes
2. Noninvasive
3. Spontaneous Breathing Trials
4. Other Ventilator Strategies
a. Differential Lung Ventilation
b. Positioning (e.g., Prone)
4. Renal
a. Infection
b. Renal Failure
c. Renal Trauma
d. Renal Transplantation (e.g., Rejection)
e. Management Strategies
f. Fluid and Electrolyte Management
g. Pharmacologic Therapies
i. Antimicrobials/Antifungals
ii. Buffers
iii. Diuretic Therapy
h. Renal Replacement Therapies: Ultrafiltration, Intermittent Hemodialysis, Peritoneal Dialysis
5. Hematologic/Oncologic
a. Bone Marrow/Stem Cell Transplantation
b. Coagulopathies
i. Acquired
a. DIC
b. Isolated Factor Abnormalities
ii. Congenital
c. Fibrinolysis
d. Hemoglobin Abnormalities
i. Anemia
ii. Polycythemia
iii. Carboxyhemoglobin
iv. Methemoglobin
v. Hemoglobinopathies (Sickle Cell Disease, Thalassemia)
e. Hypercoagulable State
f. Platelet Abnormalities
i. Thrombocytopenia (Including HIT)
ii. Thrombocytosis
iii. Other (Thrombocytopenic Purpura, ITP)
g. Tumor Lysis Syndrome
6. Obstetric
a. Coagulopathy, Bleeding Disorders
b. Emboli (Amniotic Fluid, Thromboemboli, Other)
c. Liver Function Abnormalities (e.g., Acute Fatty Liver, HELLP)
d. Pre-Eclampsia/Eclampsia
e. Peripartum Infection
7. Endocrine
a. Adrenal
1. Adrenal Insufficiency
2. Cushing Syndrome
3. Pheochromocytoma
b. Diabetes Mellitus
1. Hyperglycemia, Including Diabetic Ketoacidosis (DKA), Non-Ketotic Hyperglycemic Coma (NKHC)
2. Hypoglycemia
c. Pituitary
1. Cerebral Salt Wasting
2. Diabetes Insipidus Including Central, Nephrogenic
3. SIADH
d. Thyroid Function Abnormalities
1. Critical Illness Effects on Thyroid Function
2. Hyperthyroidism, Including Thyroid Storm
3. Hypothyroidism, Including Myxedema
8. Gastrointestinal
a. Abdominal Compartment Syndrome
b. Bowel Disorders
c. Gall Bladder Disease & Cholangitis
d. Stomach
e. GI Hemorrhage
f. GI Motility Dysfunction, GERD
g. Pancreas
h. Hepatic
1. Dysfunction/Failure, Acute and Chronic
2. Hepatic Encephalopathy
3. Hepatorenal Syndrome
4.Liver Transplantation, Rejection, Complications
5. Cirrhosis, Ascites; Paracentesis
9. Dermatologic
a. Allergic Reactions
b. Disruption Of The Skin Barrier, Including Decubiti, Stevens-Johnson Syndrome
c. Infection
d. Wound Care (Surgical and Other)
10. Immune/Infectious Disease
a. Sepsis
b. Autoimmune
c. Graph vs. Host Disease
d. Immune Suppression
i. Acquired
a. HIV/AIDS
ii. Congenital
11. Acid-Base and Electrolyte Abnormalities
12. Specialized Areas
a. Burns
i. Complications
ii. Electrical Burns
iii. Inhalation Injury
b. Disaster Management
i. Biologic, Chemical, and Nuclear Exposures
ii. Epidemic (e.g., SARS, Bird Flu, Toxic Exposures)
c. Drowning, Fatal, Near-Drowning
13. ICU Ethics
a. Brain Death
b. End-Of-Life, Futility
c. Living Will/DPOA/Healthcare Surrogate
d. Organ Donation
e. Palliative Care, Hospice
14. ICU Management and Organization
a. Clinical Care Bundles (e.g., Sepsis, Catheter Management)
b. Daily Wake-Up Test
c. ICU Transport
d. Outcome and Performance Measures (HCAHPS)
e. QA/QI (Patient Safety)
f. Scoring Systems (e.g., Apache)
g. Sedation/Analgesia/Delirium Assessment (e.g., CAM, RASS)
15. Infection Control
a. Environmental Exposures 
b. Isolation Techniques
c. Nosocomial Infections
i. Catheter Associated Infections
ii. Pneumonia (Ventilator Associated, Hospital Associated)
iii. UTI, Catheter-Associated UTI
16. Life Support and Resuscitation (ACLS, BLS, PALS, ATLS, ENLS) 
17. Nutrition Management
a. Enteral and Parenteral Nutrition (Formula, Caloric Intake)
b. Enteral Tubes
c. Metabolic Assessment (Basal and Stress Energy Requirements)
d. Re-Feeding Syndrome
18. Pharmacology (Indications, Contraindications, and Complications)
a. Antimicrobials
b. Genetic Considerations
c. Pharmacokinetics, Pharmacodynamics, and Drug Metabolism
d. Neuromuscular Blocking Drugs
e. Sedatives/Hypnotics
19. Poisonings, Toxic Ingestion, Overdoses
20. Thermoregulation
a. Hyperthermic States
b. Hypothermia- Environmental & Therapeutic
