PBLD6: Anesthetic Management of Hypertrophic Obstructive Cardiac Disease in Pregnancy Tweet to @SOAPhq Case Description Case: A 31 y/o G1P0 at 39 weeks gestation is admitted for spontaneous onset of labor with a cervical examination showing she is 2cm dilated. She has occasional contractions which she rates as a 2/10 on a pain scale of 1-10. The patient has a history of hypertrophic cardiomyopathy diagnosed at age 18. She is otherwise healthy; however, she complains of occasional dyspnea which has worsened in the last few weeks. She had one episode of syncope, with no associated trauma, 1 week ago after feeling short of breath. On examination, the patient is noted to have mild dyspnea. Physical examination was unremarkable. Vital signs: heart rate 120, non-invasive blood pressure 90/50, and category 1 fetal heart tracing. 1. Which of the following represents the best choice of management for this patient at this time? Immediate delivery of baby via Cesarean section Ephedrine IV with titration to keep higher systolic blood pressure Phenylephrine IV with titration to keep higher systolic blood pressure Placement of an epidural at this time Do nothing at this time Patients with hypertrophic cardiomyopathy (HOCM/ HCM) have enlargement of heart muscle tissue (hypertrophy of the left ventricle) with the possibility of resulting impairment of cardiac function.(1) Frequently, this is manifested by left ventricular outflow tract (LVOT) obstruction and associated mitral regurgitation.(2) In parturients in labor, pain-related sympathetic stimulation leading to an increased release of catecholamines can worsen the degree of LVOT obstruction, resulting in hemodynamic instability. Sympathomimetic medications such as ephedrine should be avoided in favor of medications such as phenylephrine which maintain a low heart rate while increasing blood pressure. Furthermore, dyspnea is a common symptom when LVOT obstruction occurs. Other symptoms associated with LVOT obstruction include dizziness, fatigue, and episodes of syncope.(3) Given that this patient’s cervical examination shows 2cm dilation and she is having mild pain, she is most likely in early labor and does not require neuraxial anesthesia at this time. Hemodynamic control of the patient with appropriate pharmacologic therapy is the best option to optimize the patient’s hemodynamic profile. References: Maron, B. J., & Braunwald, E. (2012). Evolution of hypertrophic cardiomyopathy to a contemporary treatable disease. Circulation, 126(13), 1640-1644. doi:10.1161/CIRCULATIONAHA.112.123174 Gersh, B. J., Maron, B. J., Bonow, R. O., Dearani, J. A., Fifer, M. A., Link, M. S., . . . Yancy, C. W. (2011). 2011 ACCF/AHA guideline for the diagnosis and treatment of hypertrophic cardiomyopathy: executive summary: a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines. J Am Coll Cardiol, 58(25), 2703-2738. doi:10.1016/j.jacc.2011.10.825 Stroumpoulis, K. I., Pantazopoulos, I. N., & Xanthos, T. T. (2010). Hypertrophic cardiomyopathy and sudden cardiac death. World J Cardiol, 2(9), 289-298. doi:10.4330/wjc.v2.i9.289 The patient receives phenylephrine boluses with a good response. Blood pressure increases to 110/85 and HR decreases to 75. Her dyspnea resolves. After multidisciplinary discussion with cardiologists, anesthesiologists, intensivists and maternal fetal medicine specialists, it is decided the patient will be managed expectantly for vaginal delivery. A transthoracic echocardiogram (TTE) is ordered to evaluate the degree of LVOT obstruction. 2. Which TTE view provides the best assessment of the patient’s degree of LVOT obstruction? Parasternal short axis view Parasternal long axis view Apical 4-chamber view Subcostal 4-chamber view HOCM can lead to outflow obstruction which is caused by narrowing of the LVOT due to hypertrophy of cardiac muscle. Abnormal systolic anterior motion (SAM) of the mitral valve can also lead to LVOT obstruction secondary to abnormal flow across the mitral valve pulling the mitral valve leaflets anteriorly and leading to dynamic obstruction.(4) LVOT obstruction and MR are best evaluated by the parasternal long axis view which is obtained by placing the echo transducer in the 3rd-4th intercostal space (left of sternum). With this view, the transducer orientation marker is pointing toward the patient’s right shoulder (~10 o’clock) which provides optimal visualization of the LVOT and also allows visualization of the mitral valve (see Figure 1). Image courtesy of Antonio Hernandez Conte, MD, MBA. Figure 1. Left: Correct probe location for obtaining parasternal long axis view. Probe placement is in the 3rd-4th intercostal space with the transducer orientation marker pointing toward the patient’s right shoulder. Right: Parasternal long axis view allows visualization of the left atrium, left ventricle, aortic valve and left ventricular outflow tract. Reference: 4. Sherrid MV, Gunsburg DZ, Moldenhauer S, Pearle G. Systolic anterior motion begins at low left ventricular outflow tract velocity in obstructive hypertrophic cardiomyopathy. J Am Coll Cardiol 2000; 36:1344–1354. A transthoracic echocardiogram is performed and reveals significant septal hypertrophy with an LVOT gradient of 45 mm Hg (severe). The cardiology team recommends that the patient avoid decreases in preload. At this time, the patient’s contractions have increased in frequency and duration, and her cervical examination has reached 5cm of dilation. After initially refusing an epidural, the patient expresses interest in receiving neuraxial anesthesia. 3. Which of the following describes the best anesthetic plan for this patient? Avoid neuraxial anesthesia due to concerns of decreasing preload and thereby exacerbating cardiac symptoms in favor of IV analgesia. Proceed with a combined spinal epidural to achieve rapid pain relief to avoid pain- related tachycardia and potential decreases in preload. Proceed with an epidural with slow titration to avoid rapid fluctuations in blood pressure. Avoid neuraxial and IV analgesia for anticipated vaginal delivery. Proceed with general anesthesia if patient has a Cesarean section. Epidural anesthesia can be used safely in patients with HOCM and has been shown to be safe in patients with severe LVOT obstruction.(6) Careful consideration to avoid an acute drop in preload, tachycardia, and hypotension must be ensured. Of particular importance, placement of epidural anesthesia early in the course of labor can help prevent pain-induced tachycardia, providing optimal hemodynamic conditions. Spinal anesthesia (including combined spinal epidurals) should be avoided due to the rapid drop in preload associated with sympathetic blockade, potentially exacerbating LVOT obstruction. In the event of a Cesarean section, epidural anesthesia with careful titration can be used safely. Early placement of epidural anesthesia is imperative in laboring patients due to the risks of anesthesia-related complications associated with general anesthesia should Cesarean delivery be required.(8) References: 6. DesRoches, J. M., McKeen, D. M., Warren, A., Allen, V. M., George, R. B., Kells, C., & Shukla, R. (2016). Anesthetic Management Guided by Transthoracic Echocardiography During Cesarean Delivery Complicated by Hypertrophic Cardiomyopathy. A A Case Rep, 6(6), 154-159. doi:10.1213/XAA.0000000000000275 8. Hawkins, J. L., Koonin, L. M., Palmer, S. K., & Gibbs, C. P. (1997). Anesthesia-related deaths during obstetric delivery in the United States, 1979-1990. Anesthesiology, 86(2), 277-284. The patient receives an epidural at this time. Physical examination shows a bilateral T-7 level with adequate pain relief. Unfortunately, the patient’s labor arrests at 9cm of dilation, and the decision is made to proceed with a Cesarean section. 4. Which of the following statements is true regarding left uterine displacement in regards to hemodynamic physiology in parturients? Left uterine displacement does not improve neonatal outcomes Left uterine displacement does not alter cardiac hemodynamics in patients Left uterine displacement does not cause a difference in total usage of vasoactive medication (phenylephrine or ephedrine) Left uterine displacement should be implemented in all patients at risk of hemodynamic compromise Left uterine displacement achieved with a 15 degree left tilt of the supine patient, has been shown to improve maternal hemodynamics by improving cardiac output and reducing total phenylephrine usage in patients receiving spinal anesthesia.9 Although clinically significant changes such as dizziness related to hypotension (also referred to as “supine hypotension syndrome”) only occurs in 8-10% of parturients, this practice is recommended in all parturients regardless of medical history.(10-11) In patients with HOCM, a decrease in preload and accompanying tachycardia can produce significant hemodynamic compromise by increasing the degree of LVOT obstruction. References: 10. NICE, NIfHaCE: Clinical guidelines and updates: Caesarean section. Available at: https://www.nice.org.uk/guidance/ cg132/chapter/1-guidance. Accessed May 26, 2016 11. Practice guidelines for obstetric anesthesia: An updated report by the American Society of Anesthesiologists Task Force on Obstetric Anesthesia and the Society for Obstetric Anesthesia and Perinatology. ANESTHESIOLOGY 2016; 124:270–300 5. Which of the following cardiac conditions will most likely be tolerated in patients immediately following delivery? Tricuspid regurgitation Aortic regurgitation Eisengmenger’s syndrome Aortic Stenosis Cardiovascular physiology in pregnancy and in the post-partum period is imperative for anesthesiology providers to understand. These changes have direct implications for parturients with cardiovascular conditions sensitive to abrupt hemodynamic changes that accompany pregnancy. Prominent changes include increases in cardiac output notable at 5 weeks of gestation and increasing dramatically in the immediate post-partum period.(13) To accommodate increases in blood volume and cardiac output, hormonal-induced changes dramatically decrease systemic vascular resistance beginning in the first trimester and through delivery.(13) In patients with no significant heart failure, regurgitant cardiac lesions such as mitral, tricuspid and aortic regurgitation are well tolerated in pregnancy due to the decrease in systemic vascular resistance which leads to a total decrease in regurgitant flow.(13) This decrease in systemic vascular resistance can exacerbate right-to-left shunting seen in patients with Eisenmenger syndrome.(14) However, in the immediate post-partum period, there is a significant rise in systemic vascular resistance which can exacerbate regurgitant lesions. Therefore regurgitant lesions are poorly tolerated postpartum, while the rapid increase in systemic vascular resistance is more favorable in stenotic lesions. This highlights the postpartum period as a critical interval for parturients with significant cardiac conditions and warrants close monitoring. References: 13. Hall, M. E., George, E. M., & Granger, J. P. (2011). [The heart during pregnancy]. Rev Esp Cardiol, 64(11), 1045-1050. doi:10.1016/j.recesp.2011.07.009 14. Fujitani, S., & Baldisseri, M. R. (2005). Hemodynamic assessment in a pregnant and peripartum patient. Crit Care Med, 33(10 Suppl), S354-361. Loading …