What kind of pharmacologic agent is it? NSAID
Mechanism of action? Not completely understood, thought to work by inhibiting prostaglandins
USES: pain
PharmacokineticsLiver metabolismRenal excretionPeak: 1 hr
Dose: Patients age 17 to 64: 20 mg PO once followed by 10 mg q4-6 hours prn not > 40 mg/dayPatients age ≥ 65, renally impaired, and/or weight < 50 kg (110 lbs): 10 mg PO once followed by 10 mg q4-6 hours prn not > 40 mg/day
Side Effects of Ketorolac
- GU/RENAL: cystitis, dysuria, hematuria, increased urinary frequency, interstitial nephritis, oliguria/polyuria, proteinuria, renal failure, urinary retention
- GI: anorexia, dry mouth, eructation, esophagitis, excessive thirst, gastritis, glossitis, hematemesis, hepatitis, increased appetite, jaundice, melena, rectal bleeding
- CV: congestive heart failure, palpitation, pallor, tachycardia, syncope
- Dermatologic: alopecia, photosensitivity, urticaria
- HEME: ecchymosis, eosinophilia, epistaxis, leukopenia, thrombocytopenia
- Nervous System: abnormal dreams, abnormal thinking, anxiety, asthenia, confusion, depression, euphoria, extrapyramidal symptoms, hallucinations, hyperkinesis, inability to concentrate, insomnia, nervousness, paresthesia, somnolence, stupor, tremors, vertigo, malaiseReproductive, female: infertility
- Respiratory: asthma, cough, dyspnea, pulmonary edema, rhinitis
- Special Senses: abnormal taste, abnormal vision, blurred vision, hearing loss
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